Alcohol Use Disorder (AUD) is one of the most common mental disorders and has a significant potential for harm. Although there is already a broad spectrum of effective therapies, relapse rates after therapy are high. Therefore new, complementary, and improved interventions are needed. Based on the cognitive dual-process model and neurobiological theories about the pathogenesis of AUD, therapies have already been developed in the form of alcohol-specific inhibition training (Alc-IT). Two potentially different mechanisms of actions of Alc-IT are currently discussed: Alcohol stimulus devaluation and inhibitory enhancement. In the present randomized controlled, double-blind clinical trial, the effects of Alc-IT were investigated for the first time in a clinical sample of 242 AUD patients. To address the two potential mechanisms of action, two different versions of Alc-IT were conducted, each highlighting one of the two mechanisms.